Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report.
Identifieur interne : 000710 ( Main/Exploration ); précédent : 000709; suivant : 000711Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report.
Auteurs : Min Wang [République populaire de Chine] ; Xiaohong Yang ; Fang Yang [République populaire de Chine] ; Xinxin Zhu [République populaire de Chine] ; Zhibing Sun ; Peiling Bao [République populaire de Chine] ; Yimin Yan [République populaire de Chine]Source :
- Medicine [ 1536-5964 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Betacoronavirus (MeSH), Défaillance multiviscérale (mortalité), Femelle (MeSH), Humains (MeSH), Immunisation passive (MeSH), Indice APACHE (MeSH), Infections à coronavirus (mortalité), Infections à coronavirus (thérapie), Maladie grave (mortalité), Maladie grave (thérapie), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (thérapie), Sujet âgé (MeSH), Techniques d'amplification d'acides nucléiques (MeSH), Unités de soins intensifs (MeSH), Ventilation artificielle (MeSH).
- MESH :
- mortalité : Défaillance multiviscérale, Infections à coronavirus, Maladie grave, Pneumopathie virale.
- thérapie : Infections à coronavirus, Maladie grave, Pneumopathie virale.
- Adulte d'âge moyen, Betacoronavirus, Femelle, Humains, Immunisation passive, Indice APACHE, Mâle, Pandémies, Sujet âgé, Techniques d'amplification d'acides nucléiques, Unités de soins intensifs, Ventilation artificielle.
English descriptors
- KwdEn :
- APACHE (MeSH), Aged (MeSH), Betacoronavirus (MeSH), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Critical Illness (mortality), Critical Illness (therapy), Female (MeSH), Humans (MeSH), Immunization, Passive (MeSH), Intensive Care Units (MeSH), Male (MeSH), Middle Aged (MeSH), Multiple Organ Failure (mortality), Nucleic Acid Amplification Techniques (MeSH), Pandemics (MeSH), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Respiration, Artificial (MeSH).
- MESH :
- mortality : Coronavirus Infections, Critical Illness, Multiple Organ Failure, Pneumonia, Viral.
- therapy : Coronavirus Infections, Critical Illness, Pneumonia, Viral.
- APACHE, Aged, Betacoronavirus, Female, Humans, Immunization, Passive, Intensive Care Units, Male, Middle Aged, Nucleic Acid Amplification Techniques, Pandemics, Respiration, Artificial.
Abstract
INTRODUCTION
Globally, the coronavirus disease 2019 (COVID-19) is still spreading rapidly. At present, there are no specifically approved therapeutic agents or vaccines for its treatment. Previous studies have shown that the convalescent plasma therapy (CPT) is effective in patients with COVID-19. However, its efficacy in patients with persistently positive nucleic acid test is unknown.
PATIENT CONCERNS
In this report, we present the clinical data of 5 critically ill COVID-19 patients admitted, between January 16 and February 26, 2020, in intensive care unit of Xiaogan Central Hospital.
DIAGNOSIS AND INTERVENTIONS
All these patients had a persistently positive nucleic acid test and received CPT. All 5 patients had severe respiratory failure, and thus, required invasive mechanical ventilation. The median time from the onset of symptoms to initiating the CPT was 37 (Interquartile range, 34-44) days.
OUTCOMES
Only 2 patients were cured and subsequently discharged, while 3 patients succumbed due to multiple organ failure.
CONCLUSION
The time of initiating the CPT may be an important factor affecting its efficacy, and its therapeutic effect in the treatment of COVID-19, in the late stage, is limited.
DOI: 10.1097/MD.0000000000021596
PubMed: 32898996
PubMed Central: PMC7478552
Affiliations:
Links toward previous steps (curation, corpus...)
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type="région">Hubei</region></placeName><wicri:orgArea>Medical College of Wuhan University of science and technology</wicri:orgArea></affiliation></author><author><name sortKey="Yang, Xiaohong" sort="Yang, Xiaohong" uniqKey="Yang X" first="Xiaohong" last="Yang">Xiaohong Yang</name><affiliation><nlm:affiliation>Department of Internal Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Internal Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Fang" sort="Yang, Fang" uniqKey="Yang F" first="Fang" last="Yang">Fang Yang</name><affiliation wicri:level="3"><nlm:affiliation>Medical College of Wuhan University of science and technology, Wuhan.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><wicri:orgArea>Medical College of Wuhan University of science and technology</wicri:orgArea></affiliation></author><author><name sortKey="Zhu, Xinxin" sort="Zhu, Xinxin" uniqKey="Zhu X" first="Xinxin" last="Zhu">Xinxin Zhu</name><affiliation wicri:level="3"><nlm:affiliation>Medical College of Wuhan University of science and technology, Wuhan.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><wicri:orgArea>Medical College of Wuhan University of science and technology</wicri:orgArea></affiliation></author><author><name sortKey="Sun, Zhibing" sort="Sun, Zhibing" uniqKey="Sun Z" first="Zhibing" last="Sun">Zhibing Sun</name><affiliation><nlm:affiliation>Department of Internal Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Internal Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Bao, Peiling" sort="Bao, Peiling" uniqKey="Bao P" first="Peiling" last="Bao">Peiling Bao</name><affiliation wicri:level="1"><nlm:affiliation>Blood Purification Center, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, Hubei, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Blood Purification Center, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, Hubei</wicri:regionArea><wicri:noRegion>Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Yimin" sort="Yan, Yimin" uniqKey="Yan Y" first="Yimin" last="Yan">Yimin Yan</name><affiliation wicri:level="3"><nlm:affiliation>Medical College of Wuhan University of science and technology, Wuhan.</nlm:affiliation><country>République populaire de Chine</country><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><wicri:orgArea>Medical College of Wuhan University of science and technology</wicri:orgArea></affiliation><affiliation><nlm:affiliation>Department of Internal Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Internal Medicine.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Medicine</title><idno type="eISSN">1536-5964</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>APACHE (MeSH)</term><term>Aged (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (therapy)</term><term>Critical Illness (mortality)</term><term>Critical Illness (therapy)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Immunization, Passive (MeSH)</term><term>Intensive Care Units (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Multiple Organ Failure (mortality)</term><term>Nucleic Acid Amplification Techniques (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (mortality)</term><term>Pneumonia, Viral (therapy)</term><term>Respiration, Artificial (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Défaillance multiviscérale (mortalité)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Immunisation passive (MeSH)</term><term>Indice APACHE (MeSH)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (thérapie)</term><term>Maladie grave (mortalité)</term><term>Maladie grave (thérapie)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (mortalité)</term><term>Pneumopathie virale (thérapie)</term><term>Sujet âgé (MeSH)</term><term>Techniques d'amplification d'acides nucléiques (MeSH)</term><term>Unités de soins intensifs (MeSH)</term><term>Ventilation artificielle (MeSH)</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Critical Illness</term><term>Multiple Organ Failure</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Défaillance multiviscérale</term><term>Infections à coronavirus</term><term>Maladie grave</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Critical Illness</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladie grave</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>APACHE</term><term>Aged</term><term>Betacoronavirus</term><term>Female</term><term>Humans</term><term>Immunization, Passive</term><term>Intensive Care Units</term><term>Male</term><term>Middle Aged</term><term>Nucleic Acid Amplification Techniques</term><term>Pandemics</term><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Femelle</term><term>Humains</term><term>Immunisation passive</term><term>Indice APACHE</term><term>Mâle</term><term>Pandémies</term><term>Sujet âgé</term><term>Techniques d'amplification d'acides nucléiques</term><term>Unités de soins intensifs</term><term>Ventilation artificielle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Globally, the coronavirus disease 2019 (COVID-19) is still spreading rapidly. At present, there are no specifically approved therapeutic agents or vaccines for its treatment. Previous studies have shown that the convalescent plasma therapy (CPT) is effective in patients with COVID-19. However, its efficacy in patients with persistently positive nucleic acid test is unknown.</p></div><div type="abstract" xml:lang="en"><p><b>PATIENT CONCERNS</b></p><p>In this report, we present the clinical data of 5 critically ill COVID-19 patients admitted, between January 16 and February 26, 2020, in intensive care unit of Xiaogan Central Hospital.</p></div><div type="abstract" xml:lang="en"><p><b>DIAGNOSIS AND INTERVENTIONS</b></p><p>All these patients had a persistently positive nucleic acid test and received CPT. All 5 patients had severe respiratory failure, and thus, required invasive mechanical ventilation. The median time from the onset of symptoms to initiating the CPT was 37 (Interquartile range, 34-44) days.</p></div><div type="abstract" xml:lang="en"><p><b>OUTCOMES</b></p><p>Only 2 patients were cured and subsequently discharged, while 3 patients succumbed due to multiple organ failure.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The time of initiating the CPT may be an important factor affecting its efficacy, and its therapeutic effect in the treatment of COVID-19, in the late stage, is limited.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32898996</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>23</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1536-5964</ISSN><JournalIssue CitedMedium="Internet"><Volume>99</Volume><Issue>36</Issue><PubDate><Year>2020</Year><Month>Sep</Month><Day>04</Day></PubDate></JournalIssue><Title>Medicine</Title><ISOAbbreviation>Medicine (Baltimore)</ISOAbbreviation></Journal><ArticleTitle>Convalescent plasma therapy in critically ill coronavirus disease 2019 patients with persistently positive nucleic acid test, case series report.</ArticleTitle><Pagination><MedlinePgn>e21596</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MD.0000000000021596</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Globally, the coronavirus disease 2019 (COVID-19) is still spreading rapidly. At present, there are no specifically approved therapeutic agents or vaccines for its treatment. Previous studies have shown that the convalescent plasma therapy (CPT) is effective in patients with COVID-19. However, its efficacy in patients with persistently positive nucleic acid test is unknown.</AbstractText><AbstractText Label="PATIENT CONCERNS" NlmCategory="UNASSIGNED">In this report, we present the clinical data of 5 critically ill COVID-19 patients admitted, between January 16 and February 26, 2020, in intensive care unit of Xiaogan Central Hospital.</AbstractText><AbstractText Label="DIAGNOSIS AND INTERVENTIONS" NlmCategory="UNASSIGNED">All these patients had a persistently positive nucleic acid test and received CPT. All 5 patients had severe respiratory failure, and thus, required invasive mechanical ventilation. The median time from the onset of symptoms to initiating the CPT was 37 (Interquartile range, 34-44) days.</AbstractText><AbstractText Label="OUTCOMES" NlmCategory="RESULTS">Only 2 patients were cured and subsequently discharged, while 3 patients succumbed due to multiple organ failure.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The time of initiating the CPT may be an important factor affecting its efficacy, and its therapeutic effect in the treatment of COVID-19, in the late stage, is limited.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Medical College of Wuhan University of science and technology, Wuhan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Xiaohong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Fang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Medical College of Wuhan University of science and technology, Wuhan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Xinxin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Medical College of Wuhan University of science and technology, Wuhan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Zhibing</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bao</LastName><ForeName>Peiling</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Blood Purification Center, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, The Central Hospital of Xiaogan, Xiaogan, Hubei, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Yimin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Medical College of Wuhan University of science and technology, Wuhan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Medicine (Baltimore)</MedlineTA><NlmUniqueID>2985248R</NlmUniqueID><ISSNLinking>0025-7974</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705128">COVID-19 serotherapy</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018806" MajorTopicYN="N">APACHE</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007116" MajorTopicYN="N">Immunization, Passive</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009102" MajorTopicYN="N">Multiple Organ Failure</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021141" MajorTopicYN="N">Nucleic Acid Amplification Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" 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IdType="pubmed">32253318</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><noCountry><name sortKey="Sun, Zhibing" sort="Sun, Zhibing" uniqKey="Sun Z" first="Zhibing" last="Sun">Zhibing Sun</name><name sortKey="Yang, Xiaohong" sort="Yang, Xiaohong" uniqKey="Yang X" first="Xiaohong" last="Yang">Xiaohong Yang</name></noCountry><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Wang, Min" sort="Wang, Min" uniqKey="Wang M" first="Min" last="Wang">Min Wang</name></region><name sortKey="Bao, Peiling" sort="Bao, Peiling" uniqKey="Bao P" first="Peiling" last="Bao">Peiling Bao</name><name sortKey="Yan, Yimin" sort="Yan, Yimin" uniqKey="Yan Y" first="Yimin" last="Yan">Yimin Yan</name><name sortKey="Yang, Fang" sort="Yang, Fang" uniqKey="Yang F" first="Fang" last="Yang">Fang Yang</name><name sortKey="Zhu, Xinxin" sort="Zhu, Xinxin" uniqKey="Zhu X" first="Xinxin" last="Zhu">Xinxin Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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